This course combines themes from mechanics, electromagnetics, thermal physics, and neural networks with an introduction to numerical methods as well as the use of MATLAB. Students will become familiar with the underlying theory for a variety of systems in physics and biology (e.g., harmonic, anharmonic and coupled oscillators; electric fields of electric lenses; geo-thermal power station; and artificial neural networks), derive the necessary mathematical equations describing these systems, learn the necessary numerical methods to solve the underlying equations, and implement the system equations and numerical methods in MATLAB to simulate these systems. As a result, students will be prepared to formulate problems or model systems in physics, biology, and related disciplines, and to solve them numerically or in simulation.